Everytime I attempt to debug in VB2005 Express I get a message box eroor stating
"Error trying to run project: Unable to start debugging. The binding handle is invalid".
What is causing this I can compile and deploy the application, no problem.
I even tried the well known, very simple "Hello World", and it does the same thing.

The binding handle is invalid
Bo_
Maybe this:
http://connect.microsoft.com/VisualStudio/feedback/ViewFeedback.aspx FeedbackID=105751
https://blogs.msdn.com/habibh/archive/2005/11/10/491572.aspx
will help you out...
Best regards,
Johan Stenberg