https://forums.microsoft.com/MSDN/ShowPost.aspx PostID=1175234&SiteID=1
And answering his question, yes NCSoft and Cryptic Studios are the makers of City of Heros
None of the compatibility options fix or help the issue... unfortunately :(
Yes my graphics card is up to speed and beyond what is required to run the game. I was just wondering if there was anything else I could do to possibly get the game to run properly However, don't think thats going to happen anytime soon... i found something on the NC Support forums asking about it which was a complete bummer....
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Question
Can I play the game with WindowsR Vista
Answer
WindowsR Vista is not a supported operating system for any NCsoft game. This may change in the near future. However, it may remain unsupported for some games. Check back with this support site for future changes.
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thats very nice of them, since i pay to play 2 of them and own 3 other games .....

Windows Vista Game Issues